Long-Term Morbidity after Postoperative Hypoparathyroidism in Thyroid Cancer Patients: A Nationwide Population-Based Cohort Study
Authors' conclusion
PO-hypoPT in thyroid cancer patients is associated with increased long-term morbidity, particularly renal and cardiovascular complications. Long-term monitoring of renal function and cardiovascular health is warranted in this population.
Study context
- Population
- Thyroid cancer patients who underwent thyroidectomy 2013–2020, South Korea nationwide claims data (OMOP Common Data Model)Propensity score (PS)-matched cohort
- Participants
- 15,592 vs 27,906
- Exposure
- Permanent postoperative hypoparathyroidism vs preserved parathyroid function
- Postoperative hypoparathyroidism (PO-hypoPT)n = 15,592
- Preserved parathyroid functionn = 27,906reference
- Outcome
- Long-term morbidities associated with hypoparathyroidism (hypoPT): nephrolithiasis, renal insufficiency, major adverse cardiac events (MACE), seizures, infections, cataracts, depression
- Follow-up
- Median ≈5 years
Methodological detailsnationwide, population-based, 1:2 propensity score matched
- Nationwide
- Population-based
- 1:2 propensity score matched
Main finding
As reported in the abstract
Long-term morbidities
PO-hypoPT vs Preserved parathyroid functionHazard ratio (CI)
Nephrolithiasis
1.17(1.04–1.30)
Renal insufficiency
1.75(1.50–2.03)
MACE
1.10(1.01–1.19)
Observational data: associations, not effects.
Further findings
Renal insufficiency by subgroup (sex, age, duration of calcium supplementation)
- Association between PO-hypoPT and renal insufficiency consistent across all subgroups
Original publication
Long-Term Morbidity after Postoperative Hypoparathyroidism in Thyroid Cancer Patients: A Nationwide Population-Based Cohort Study. Thyroid. Published 18 February 2026. doi:10.
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