Osteoporotic fracture risk in hypoparathyroidism following total thyroidectomy: a retrospective nationwide cohort study
Authors' conclusion
Hypoparathyroidism after total thyroidectomy does not appear to increase the risk of osteoporotic fractures compared with that in matched controls in clinical practice.
Study context
- Population
- Patients with hypoparathyroidism after total thyroidectomy for thyroid cancer and matched controls, Korean National Health Insurance Service-National Sample Cohortpropensity score matched
- Participants
- 417 vs 2,085
- Exposure
- Postoperative hypoparathyroidism after total thyroidectomy for thyroid cancer vs matched controls
- TC with hypoPn = 417
- Matched controlsn = 2,085reference
- Outcome
- Osteoporotic fractures
- Follow-up
- Median 5.07 years (IQR 2.19-7.38)
Methodological detailsnationwide, propensity score matching
- Nationwide
- Propensity score matching
Main finding
As reported in the abstract
Postoperative hypoparathyroidism vs control group, HR (95% CI 0.59-1.24, P = .406); not associated with significantly greater risk
0.86
Observational data: associations, not effects.
Further findings
Osteoporotic fractures, patients aged <50 years
- Age-specific analysis, aged <50 years, HR (95% CI 0.53-3.22, P = .558); trend toward higher fracture incidence, not statistically significant
- 1.31
Osteoporotic fractures, patients aged ≥50 years
- Age-specific analysis, aged ≥50 years, HR (95% CI 0.51-1.12, P = .163); decreasing trend, not statistically significant
- 0.75
Fracture risk by fracture site
- No significant differences in fracture risk between TC with and without hypoP across all fracture sites
Osteoporotic medication use
- Higher in TC with hypoP than control group, particularly among women aged <50 years
Original publication
Osteoporotic fracture risk in hypoparathyroidism following total thyroidectomy: a retrospective nationwide cohort study. Eur J Endocrinol. Published 17 June 2025. doi:10.
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