Risk of Fractures in Thyroid Cancer Patients With Postoperative Hypoparathyroidism: A Nationwide Cohort Study in Korea
Main finding · Any fracturesResult — go to the resultHazard ratio 0.83 95% CI 0.70–0.98Authors' conclusion
PO-hypoPT was associated with a lower risk of fractures in thyroid cancer patients, especially at the vertebra.
Study context
- Population
- Korean thyroid cancer patients aged ≥18 years who underwent total thyroidectomy between 2008 and 2016; Korea Central Cancer Registry and National Health Insurance Service data
- Participants
- 115,821 patients
- Exposure
- Postoperative hypoparathyroidism (PO-hypoPT) vs preserved parathyroid function after total thyroidectomy
- PO-hypoPTn = 8,789
- Preserved parathyroid functionn = 107,032reference
- Outcome
- Any fractures, including vertebral, hip, humerus and wrist fractures
- Follow-up
- Mean 4.8 years
Methodological detailsnationwide, multivariable Cox proportional hazard model
- Nationwide
- Multivariable Cox proportional hazard model
Main finding
Any fractures
Hazard ratio
0.83
95% CI 0.70–0.98
P = 0.037
Events by group
PO-hypoPTvs Preserved parathyroid function
HR 0.83 (95% CI 0.70–0.98); P = 0.037
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Vertebral fracturesAdjusted for confounders | 0.67 (0.47–0.96) | P = 0.028 | |
| 0.512Hazard ratio (log scale) |
Vertebral fractures
- Only vertebral fracture risk was significantly lower among fracture sites
Subgroup interactions for any fractures
- BMD measurements interacted with PO-hypoPT–fracture relationship
- p for interactions = 0.010
- Calcium supplementation interacted with PO-hypoPT–fracture relationship
- p for interactions = 0.017
Original publication
Risk of Fractures in Thyroid Cancer Patients With Postoperative Hypoparathyroidism: A Nationwide Cohort Study in Korea. J Bone Miner Res. Published 5 July 2023. doi:10.
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