Long-term Nonskeletal Complications in Patients With Thyroid Cancer and Hypoparathyroidism Post Total Thyroidectomy
Authors' conclusion
Patients with TC with hypoP are at an increased risk for specific nonskeletal complications, particularly older adults and women. These findings underscore the need for targeted monitoring and management strategies in this population. Further prospective studies are warranted to validate these associations and elucidate the underlying mechanisms.
Study context
- Population
- Patients with thyroid cancer diagnosed 2006–2019, National Health Insurance Service-National Sample Cohort
- Exposure
- Thyroid cancer (TC) with hypoparathyroidism vs TC without hypoparathyroidism vs matched controls
- TC with hypoPn = 430
- TC without hypoPn = 850
- Outcome
- Incidence and risk of nonskeletal complications: DM, dyslipidemia, cardiovascular and renal outcomes, cataracts
Methodological detailspropensity score matching, Cox proportional hazards models, National Health Insurance Service-National Sample Cohort (2002-2019)
- Propensity score matching
- Cox proportional hazards models
- National Health Insurance Service-National Sample Cohort (2002-2019)
Main finding
As reported in the abstract
Nonskeletal complications, TC with hypoP vs controls
TC with hypoP vs ControlsHazard ratio (95% CI)P value
Diabetes mellitus
1.31(1.01–1.68)
P < 0.05Dyslipidemia
1.29(1.06–1.57)
P < 0.05Urinary stones
1.61(1.00–2.57)
P < 0.05Cataracts
1.50(1.15–1.95)
P < 0.05Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Hypertension, TC with hypoPvs TC without hypoP | 1.39 (1.00–1.93) | P = 0.048 | |
| 0.512Hazard ratio (log scale) |
Subgroups
- Women had higher urinary stone risk
- Cataract risk increased in patients aged over 50
Original publication
Long-term Nonskeletal Complications in Patients With Thyroid Cancer and Hypoparathyroidism Post Total Thyroidectomy. J Clin Endocrinol Metab. Published 2 April 2025. doi:10.
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