Association between bone mineral density (BMD) and coronary artery calcification: an observational and Mendelian randomization study
Authors' conclusion
Our results do not support the contention that lower BMD is (causally) associated with an increased CAC risk.
Study context
- Population
- Individuals from the Rotterdam Study (mean age 69.9 yr, 52.0% women) and the Framingham Heart Study (mean age 56.5 yr, 50.9% women) with complete coronary artery calcification (CAC) and BMD measurements at total body, lumbar spine and femoral neck1,414 Rotterdam
- Exposure
- BMD and CAC
- Outcome
- Association between BMD and CAC (observational linear regression; MR primary methods: 2-stage least squares and inverse variance weighted (IVW))
Methodological details2 population-based cohorts, polygenic risk scores, 1- and 2-sample Mendelian randomization
- 2 population-based cohorts
- Polygenic risk scores
- 1- and 2-sample Mendelian randomization
Main finding
As reported in the abstract
BMD and CAC
- Mean CAC uniformly distributed across PRS-BMD quintile groups
- P-value > .05
Observational data: associations, not effects.
Original publication
Association between BMD and coronary artery calcification: an observational and Mendelian randomization study. J Bone Miner Res. Published 4 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →