Risk factors for hip and vertebral fractures in chronic kidney disease: the chronic renal insufficiency cohort (CRIC) study
Authors' conclusion
In conclusion, lower eGFR in CKD is associated with higher fracture risk, which was highest in kidney failure.
Study context
- Population
- Adults with chronic kidney disease (CKD) in the Chronic Renal Insufficiency Cohort (CRIC); mean age 58 years, 45% female, 42% Black, 13% Hispanic
- Participants
- 3,939 adults
- Exposure
- Putative risk factors for composite of first hip or vertebral fracture
- Outcome
- Composite of:
- First hip
- Vertebral fracture
- Follow-up
- Mean (SD) 11.1 (4.8) years
Methodological detailsCox regression, time-updated exposures
- Cox regression
- Time-updated exposures
Main finding
As reported in the abstract
First hip or vertebral fracture
Each group vs eGFR ≥60Hazard ratio (95% CI)
Dialysis
4.53(1.77–11.60)
Post-kidney transplantation
2.48(0.86–7.14)
- Hip fractures
- 82
- Vertebral fractures
- 24
- Fracture incidence
- 2.4 events per 1000 person-years (95% CI: 2.0, 2.9)
- Lower time-updated estimated glomerular filtration rate (eGFR), HR per 10 mL/min/1.73m2 lower eGFR
- 1.20 (95% CI: 1.04, 1.38)
Observational data: associations, not effects.
Original publication
Risk factors for hip and vertebral fractures in chronic kidney disease: the CRIC study. J Bone Miner Res. Published 4 February 2024. doi:10.
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