Bone microarchitecture declines in older men with impaired renal function—the prospective STRAMBO study
An erratum to this article was published (J Bone Miner Res, 3 Sep 2026 ↗)
Authors' conclusion
Lower eGFR is associated with a faster decline in cortical bone microarchitecture and bone strength at the distal radius and tibia in older men.
Study context
- Population
- Older men aged ≥60; bone microarchitecture at distal radius and tibia by HR-pQCT at baseline, 4 and 8 yr
- Participants
- 826 men
- Exposure
- Lower vs higher estimated glomerular filtration rate (eGFR)
- Outcome
- Changes in bone microarchitecture (HR-pQCT) across eGFR classes
- Follow-up
- 8 yr
Methodological details8-yr follow-up, linear mixed effect models
- 8-yr follow-up
- Linear mixed effect models
Main finding
As reported in the abstract
Changes in bone microarchitecture by eGFR · 8 yr follow-up
- Distal radius: lower eGFR associated with more rapid decrease in Tt.BMD, Ct.Ar, Ct.BMD, Tb.BMD and failure load
- Distal radius: low eGFR associated with faster increase in Tb.Ar and Tb.1/N.SD
- Distal tibia: low eGFR associated with more rapid decrease in Tt.BMD, Ct.Ar, Ct.BMD, Tb.1/N.SD and failure load, and faster increase in Tb.Ar
- Patterns similar for changes as percentages and for 2 other equations
Observational data: associations, not effects.
Further findings
Baseline bone microarchitecture by eGFR (CKDEPI-2012)
- Distal radius microarchitecture did not differ across eGFR groups
- Distal tibia trabecular measures and failure load higher in men with decreased eGFR
Original publication
Bone microarchitecture declines in older men with impaired renal function—the prospective STRAMBO study. J Bone Miner Res. Published 28 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →