Rapid Cortical Bone Loss at the Distal Radius Is Associated With Higher Risk of Fracture in Older Men – The STRAMBO Study
Authors' conclusion
Thus, rapid cortical bone loss at the distal radius is associated with higher fracture risk in the multivariable models including baseline values of the HR-pQCT measure.
Study context
- Population
- Older men aged 60–87 years (STRAMBO study); bone microarchitecture at distal radius and tibia by high-resolution peripheral QCT (HR-pQCT)109 with fragility fractures
- Participants
- 732 men
- Exposure
- Faster vs slower decline in bone microarchitecture per SD
- Outcome
- Fragility fracture risk by rate of bone microarchitecture decline
- Follow-up
- 8-year follow-up
Methodological detailsrepeated HR-pQCT (baseline, 4 years), 8-year follow-up
- Repeated HR-pQCT (baseline, 4 years)
- 8-year follow-up
Main finding
As reported in the abstract
Faster decrease in distal radius Tt.BMD and fracture risk (adjusted for age, weight, prior falls and fractures, distal radius aBMD baseline and slope, baseline Tt.BMD)
HR per SD
1.54
95% CI 1.20–1.95p < .005
Observational data: associations, not effects.
Further findings
Rapid cortical bone loss at distal radius and fracture risk
- Cortical thickness: HR
- 1.48 (1.15-1.90, p < .01)
- Cortical BMD: HR
- 1.38 (1.11-1.72, p < .01)
Trabecular bone loss at distal radius; microarchitecture decline at distal tibia
- Not associated with fracture risk
Changes in Tt.BMD, adjusted for areal bone mineral density (aBMD) and distal radius HR-pQCT measures at 4 years
- Tt.BMD: HR
- 1.37 (1.11-1.69, p < .005)
Fracture prediction vs reference model
- Adding slope of HR-pQCT measure did not improve fracture prediction
Original publication
Rapid Cortical Bone Loss at the Distal Radius Is Associated With Higher Risk of Fracture in Older Men – The STRAMBO Study. J Bone Miner Res. Published 29 March 2023. doi:10.
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