The Vitamin D Metabolite Ratio Is Associated With Volumetric Bone Density in Older Men
Authors' conclusion
Among older men, a higher VMR was associated with greater vBMD and bone strength while 25(OH)D3 was not. The VMR may serve as a valuable marker of skeletal health in older men.
Study context
- Population
- Older men in the Osteoporotic Fractures in Men (MrOS) Study; mean age 84 ± 4 years, 88.3% White, 32% eGFR <60 mL/min/1.73 m²
- Participants
- 545 men
- Exposure
- VMR and 25D3 vs volumetric BMD (vBMD) and bone strength
- Outcome
- vBMD and estimated failure load (EFL, bone strength) at the distal radius and tibia, by high-resolution peripheral quantitative computed tomography (HR-pQCT)
Main finding
As reported in the abstract
Higher total vBMD at distal radius per twofold higher VMR
9%
3%, 16%
Higher estimated failure load (EFL) at distal radius per twofold higher VMR
13%
5%, 21%
Observational data: associations, not effects.
Original publication
The Vitamin D Metabolite Ratio Is Associated With Volumetric Bone Density in Older Men. J Clin Endocrinol Metab. Published 6 October 2023. doi:10.
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