Reference limits for osteocalcin in infancy and early childhood: A longitudinal birth cohort study
Authors' conclusion
Osteocalcin followed a wavelike pattern with low levels in the umbilical cord and a postnatal peak during the first year which then declined and rose again by the age of five. Knowledge of this wavelike pattern and association to factors as sex, breastfeeding and GA may help clinicians to interpret individual osteocalcin levels and guide in future research.
Study context
- Population
- Swedish children, blood samples at birth, 4, 12, 36 and 60 months of age
- Participants
- 551 children
- Exposure
- Boys vs girls
- Outcome
- Reference limits for total serum osteocalcin (IDS-iSYS N-MID Osteocalcin assay)
- Follow-up
- Birth until 5 years of age
Main finding
As reported in the abstract
Boys: median osteocalcin at birth, 4, 12, 36, 60 months
40.8, 90.0, 67.8, 62.2 and 80.9 μg/L
Girls: median osteocalcin at birth, 4, 12, 36, 60 months
38.1, 95.5, 78.3, 73.9 and 92.6 μg/L
Observational data: associations, not effects.
Further findings
Associations with gestational age (GA) and breastfeeding
- Lower GA was associated with higher osteocalcin at birth
- Ongoing breastfeeding was associated with higher osteocalcin levels
Original publication
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