Hypoparathyroidism and mortality after total thyroidectomy: A nationwide matched cohort study
Main finding · All-cause deathResult — go to the resultHazard ratio 1.34 95% CI 1.15–1.56Authors' conclusion
The use of active vitamin D for hypoPT was prevalent one year after TT. Patients with hypoPT did not have an increased risk of mortality following TT unless the indication was due to malignancy.
Study context
- Population
- Danish individuals undergoing total thyroidectomy (TT), 1998–2017; Hypoparathyroidism (hypoPT) defined as active vitamin D treatment after 12 months postoperatively
- Participants
- 7,912 TT patients
- Exposure
- TT patients with hypoPT vs matched comparison cohort
- TTn = 7,912
- Outcome
- Frequency of hypoPT and all-cause mortality
Methodological detailsnationwide, matched on sex and birth year, population-based registries
- Nationwide
- Matched on sex and birth year
- Population-based registries
Main finding
All-cause death · 12 months postoperatively
Hazard ratio
1.34
95% CI 1.15–1.56
TT with hypoPTvs Comparison
HR 1.34 (95% CI 1.15–1.56)
As reported in the abstract
- Prevalence of hypoPT 12 months postoperatively
- 16.6%
Observational data: associations, not effects.
Further findings
All-cause mortality with hypoPT after TT, by indication for surgery (subgroup analysis)
- Malignancy: mortality increased, HR
- 2.48; 1.99-3.10 (95% CI)
- Goitre (benign): mortality not increased, HR
- 0.88; 0.68-1.15 (95% CI)
- Thyrotoxicosis (benign): mortality not increased, HR
- 0.86; 0.57-1.28 (95% CI)
Original publication
Hypoparathyroidism and mortality after total thyroidectomy: A nationwide matched cohort study. Clin Endocrinol (Oxf). Published 20 February 2024. doi:10.
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