Increased Risk of Chronic Kidney Disease After Total Thyroidectomy: A Nationwide Matched Cohort Study
Authors' conclusion
HypoPT was a frequent complication after TT and was associated with an increased risk of CKD. We also found an increased risk of CKD in patients with a normal parathyroid function after TT, which needs to be further evaluated.
Study context
- Population
- All Danish individuals with total thyroidectomy (TT), January 1998–December 2017
- Participants
- 2,421 TT patients
- Exposure
- TT with hypoparathyroidism (hypoPT) and TT without hypoPT vs matched comparison cohort
- Outcome
- CKD (cumulative incidence and HR)
- Follow-up
- 10 years
Methodological detailspopulation-based registries, matched by sex and birth year (10 comparators per patient)
- Population-based registries
- Matched by sex and birth year (10 comparators per patient)
Main finding
As reported in the abstract
CKD
Each group vs comparisonAdjusted hazard ratio (95% CI)
HypoPT
3.23(2.37–4.41)
Without hypoPT
2.27(1.87–2.75)
Observational data: associations, not effects.
Further findings
Chronic kidney disease (CKD) by comorbidity (Charlson Comorbidity Index)
- Adjusted HR of CKD higher in patients without previous comorbidities than in patients with several comorbidities
Original publication
Increased Risk of Chronic Kidney Disease After Total Thyroidectomy: A Nationwide Matched Cohort Study. J Clin Endocrinol Metab. Published 10 August 2024. doi:10.
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