Increased risk of vertebral fractures and reduced risk of femur fractures in patients with chronic hypoparathyroidism: a nationwide cohort study in Sweden
Main finding · MOFResult — go to the resultHazard ratio 0.93 95% CI 0.69–1.26Authors' conclusion
In this large Swedish cohort, chronic hypoPT was not associated with an increased risk of MOF. Vertebral fracture risk was higher, while the femur fracture risk was lower compared to controls.
Study context
- Population
- Patients with chronic hypoparathyroidism treated with active vitamin D, 1997–2018, Sweden (National Patient, Prescribed Drug and Total Population Registers)matched cohort
- Participants
- 1,915 vs 15,838
- Exposure
- Chronic hypoparathyroidism (hypoPT) vs matched controls
- Chronic hypoPTn = 1,915
- Controlsn = 15,838reference
- Outcome
- Major osteoporotic fracture (MOF)
Methodological detailsmatched controls, register-based
- Matched controls
- Register-based
Main finding
MOF
Hazard ratio
0.93
95% CI 0.69–1.26
Chronic hypoPTvs Controls
HR 0.93 (95% CI 0.69–1.26)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Vertebral fractures | 1.55 (1.12–2.14) | |
| Femur fractures | 0.70 (0.50–0.98) | |
| Osteoporosis diagnosis | 1.54 (1.21–1.95) | |
| Osteoporosis medication prescribed | 0.69 (0.54–0.88) | |
| 0.512Hazard ratio (log scale) |
Major osteoporotic fracture (MOF) by subgroup (sex; surgical vs non-surgical hypoPT)
- No difference in MOF risk between females and males
- P for interaction = 0.872
- No difference in MOF risk between surgical and non-surgical chronic hypoPT
- P for interaction = 0.072
Original publication
Increased risk of vertebral fractures and reduced risk of femur fractures in patients with chronic hypoparathyroidism: a nationwide cohort study in Sweden. J Bone Miner Res. Published 5 May 2025. doi:10.
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