Vitamin D and tibial bone density, geometry, and microarchitecture in male military recruits: an observational study and randomized controlled trial
Authors' conclusion
Vitamin D metabolites and their ratios were associated with tibial size and microarchitecture, but vitamin D supplementation had no impact on the adaptive response to military training.
Study context
- Population
- Male British Army recruits in initial military training343 (Study 1), 194 (Study 2)
- Comparison
- Vitamin D supplementation vs placebo for 12 wk
Methodological detailsplacebo-controlled
- Placebo-controlled
Primary result
As reported in the abstract
Associations of vitamin D metabolites with tibial HRpQCT outcomes (Study 1) · week 1
- No association between total 25(OH)D or vitamin D receptor single-nucleotide polymorphisms and any measure of density, geometry, or microarchitecture
- p ≥ .063
- Higher 1,25(OH)2D associated with lower cortical porosity and perimeter
- p ≤ .040
Further findings
Tibial change with training · week 1 to week 12
- Trabecular area
- −0.1%
- Trabecular thickness
- −4.4%
- Trabecular separation
- −2.1%
- Cortical thickness
- 0.8%
- Cortical area
- 0.9%
- p ≤ .042
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Vitamin D and tibial bone density, geometry, and microarchitecture in male military recruits: an observational study and randomized controlled trial. J Bone Miner Res. Published 5 May 2025. doi:10.
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