Critical Role for 24-Hydroxylation in Homeostatic Regulation of Vitamin D Metabolism
Study context
- Population
- Otherwise healthy community participants with vitamin D (VitD) deficiency (25(OH)D ≤20 ng/mL)
- Participants
- 11 participants
- Comparison
- Before vs after VitD3 supplementation
- Outcome
- VitD metabolites and 24-hydroxylase activity after VitD3 supplementation
- Follow-up
- Before and after VitD3 supplementation
Methodological detailscrossover, before and after VitD3 supplementation
- Crossover
- Before and after VitD3 supplementation
Main finding
As reported in the abstract
before and after VitD3 supplementation
Mean 25(OH)D increased with VitD3 supplementation
2.7-fold
24,25(OH)2D increased with VitD3 supplementation
4.3-fold
Correlation of total plasma 25(OH)D with modeled 24-hydroxylase activity (h)
ρ = 0.51
P = .01
Correlation of 24,25(OH)2D/25(OH)D ratio with modeled 24-hydroxylase activity (h)
ρ = 0.37
P = .3
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Critical Role for 24-Hydroxylation in Homeostatic Regulation of Vitamin D Metabolism. J Clin Endocrinol Metab. Published 14 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →