Genome-wide association study of osteoporosis identifies genetic risk and interactions with Dietary Approaches to Stop Hypertension diet and sugar-sweetened beverages in a Hispanic cohort of older adults
Authors' conclusion
This study identifies new genetic markers related to OP and BMD in older Hispanic adults. Additionally, we uncovered unique genetic markers that interact with dietary quality, specifically SSBs, in relation to bone health.
Study context
- Population
- Older Hispanic adults, Boston Puerto Rican Osteoporosis (BPROS) study; bone measured by dual-energy X-ray absorptiometry; Osteoporosis (OP) defined as T-score ≤ −2.5
- Participants
- 978 adults
- Outcome
- Genome-wide associations with bone outcomes, including BMD and OP
Methodological detailsancillary study to the Boston Puerto Rican Health Study (BPRHS), gene-diet interaction analysis, Dietary variables collected at second wave of BPRHS via food frequency questionnaire
- Ancillary study to the Boston Puerto Rican Health Study (BPRHS)
- Gene-diet interaction analysis
- Dietary variables collected at second wave of BPRHS via food frequency questionnaire
Main finding
As reported in the abstract
Variants associated with OP: rs114829316 (IQ motif containing J gene), rs76603051, rs12214684 (melanin-concentrating hormone receptor 2 gene), rs77303493 (Ras and Rab interactor 2 gene)
4
Variants associated with BMD: lumbar spine (rs11855618, cingulin-like 1 gene) and hip (rs73480593, NTRK2)
2
Further findings
Gene-diet interaction
- SNPs with significant interaction with overall Dietary Approaches to Stop Hypertension (DASH) score
- 1
- SNPs with significant interaction with sugar-sweetened beverages (SSBs)
- 7
Original publication
Genome-wide association study of osteoporosis identifies genetic risk and interactions with Dietary Approaches to Stop Hypertension diet and sugar-sweetened beverages in a Hispanic cohort of older adults. J Bone Miner Res. Published 14 March 2024. doi:10.
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