Bone Structural Parameters as Measured by 3-Dimensional Dual-Energy X-Ray Absorptiometry Are Superior in Black Women and Demonstrate Unique Associations With Prior Fracture Versus White Women
Authors' conclusion
3D-DXA parameters were superior in Black women than in White women, and cortical thickness of the FN was associated with fractures only in Black women. 3D-DXA may improve fracture risk assessment in Black patients.
Study context
- Population
- Women previously recruited from an osteoporosis clinic who had undergone DXA and vertebral fracture assessment
- Participants
- 775 participants
- Comparison
- Black vs White women
- Blackn = 368
- Whiten = 407reference
Methodological detailsretrospective 3D-DXA on proximal femur bone mineral density (BMD) scan
- Retrospective 3D-DXA on proximal femur BMD scan
Primary result
As reported in the abstract
3D-DXA bone structural parameters
- Black women had generally superior 3D-DXA parameters, largest differences in femoral neck (FN) cortical thickness and FN buckling ratio
- Substantial differences in associations between fracture and 3D-DXA parameters in Black vs White women
Further findings
| Outcome | Black |
|---|---|
| Association of FN cortical thickness with prior fracture, adjusted for age, glucocorticoids and areal BMD T-score | |
| OR per SD decline | 1.4 (95% CI 1.0-1.9; P = .04) |
Association of FN cortical thickness with prior fracture, adjusted for age, glucocorticoids and areal BMD T-score
- Not significantly associated in White women
Original publication
Bone Structural Parameters as Measured by 3-Dimensional Dual-Energy X-Ray Absorptiometry Are Superior in Black Women and Demonstrate Unique Associations With Prior Fracture Versus White Women. Endocr Pract. Published 7 November 2024. doi:10.
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