Possible role of bone turnover markers in the diagnosis of adult hypophosphatasia
Authors' conclusion
In cases of low ALP and bone fragility, BTM and their ratios could help distinguish HPP patients from osteoporotic individuals treated with antiresorptive drugs, aiding in accurate diagnosis and reducing the risk of inappropriate treatment.
Study context
- Population
- Adults with hypophosphatasia (HPP) and women with osteoporosis on antiresorptive treatment; primary analysis in 16 female HPP patients16 female HPP in primary analysis
- Participants
- 23 vs 46
- Comparison
- Adults with HPP vs osteoporotic subjects previously treated with zoledronic acid or denosumab
- HPPn = 23
- Osteoporosisn = 46reference
- Outcome
- Discriminatory power (AUC) of bone turnover markers (BTMs) (CTX, P1NP, total ALP, bALP) and BTM ratios to differentiate HPP from treated osteoporosis
Methodological detailsmulticenter
- Multicenter
Performance
As reported in the abstract
Discrimination of HPP from treated osteoporosis
| Test or model | AUC | Cut-off |
|---|---|---|
| P1NP | 0.962 | 32 μg/L |
| Alkaline phosphatase (ALP)/P1NP ratio | 0.964 | 1.114 |
AUC
P1NP0.962
Alkaline phosphatase (ALP)/P1NP ratio0.964
Cut-off
P1NP32 μg/L
Alkaline phosphatase (ALP)/P1NP ratio1.114
Further findings
Including male HPP patients, adjusting for age and sex, and sensitivity analysis in ALP ≤32 U/L
- Similar results confirmed
- Sensitivity analysis
Original publication
Possible role of bone turnover markers in the diagnosis of adult hypophosphatasia. J Bone Miner Res. Published 5 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →