Osteoporosis, bone & mineral

Vertebral fracture prevalence and risk factors for fracture in The Gambia, West Africa: the Gambian Bone and Muscle Ageing Study

J Bone Miner ResPublished Prospective observational study

An erratum to this article was published (J Bone Miner Res, 3 Feb 2026 ↗)

Authors' conclusion

VF prevalence in Gambian older adults is similar to elsewhere, despite fractures not being a perceived issue. Risk factors were like those identified elsewhere, including age, aBMD, and bone resorption.

Study context

Population
Men and women aged 40 yr and over, rural and urban The Gambia, West Africa (Gambian Bone and Muscle Ageing Study)298 women
Participants
581 men
Outcome
Prevalence of VF on DXA
Follow-up
Baseline
Methodological detailsrural cohort followed up 6-8 yr later; urban single measurement, DXA-based vertebral fractures (VF) assessment
  • Rural cohort followed up 6-8 yr later; urban single measurement
  • DXA-based VF assessment

Main finding

As reported in the abstract

Prevalence of VF

Prevalence of VF

14.8%

Observational data: associations, not effects.

Further findings

Age, VF vs no VF · baseline · older with VF

P = 0.01

Age, VF vs no VF · baseline

Those with VF had lower areal BMD (aBMD) Z-scores

Prevalent VF per 1 SD increase in femoral neck Z-score, women · baseline

OR
0.51 [0.38, 0.73] (95% CI)

Prevalent VF by lumbar spine Z-score, men · baseline

OR
0.71 [0.53, 0.97] (95% CI)

Incidence of VF · over follow-up (6-8 yr)

Incidence of VF
12.1%
Low BMD and grip strength associated with odds of incident VF

Original publication

Vertebral fracture prevalence and risk factors for fracture in The Gambia, West Africa: the Gambian Bone and Muscle Ageing Study. J Bone Miner Res. Published 7 November 2024. doi:10.1093/jbmr/zjae182

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