Longitudinal Change in Bone Density, Geometry, and Estimated Bone Strength in Older Men and Women From The Gambia: Findings From the Gambian Bone and Muscle Aging Study (GamBAS)
Authors' conclusion
The magnitude of bone loss was like those reported in countries where fragility fracture rates are much higher.
Study context
- Population
- Gambian adults aged 40 years and older (GamBAS)386 attended follow-up
- Participants
- 488 adults
- Exposure
- Women vs Men
- Outcome
- Mean annualized percentage change in bone outcomes (DXA total hip aBMD, BMC, bone area; Peripheral quantitative computed tomography (pQCT) radius and tibia vBMD, BSIc, CSA, BMC, cortical vBMD) in 10-year age bands
- Follow-up
- 1.7 years
Methodological detailslongitudinal, stratified by sex and 5-year age band
- Longitudinal
- Stratified by sex and 5-year age band
Main finding
As reported in the abstract
Annualized bone change
Annual loss of total hip areal bone mineral density (aBMD) in women after age 50 years and in men aged 70+ years
1.2%
Radius strength (bone strength indices (BSIc)) reduction per year, women
4%
p trend 0.02
Radius strength (BSIc) reduction per year, men
3%
p trend 0.03
Cortical bone mineral content (BMC) loss in women, per annum
between 1.4% and 2.0%
Observational data: associations, not effects.
Further findings
Predictors of bone change
- Higher CTX and PINP predicted greater loss of radius trabecular volumetric BMD (vBMD) in women and BMC in men
- Higher 25(OH)D predicted less loss of tibial trabecular vBMD and cross-sectional area (CSA) in women
Original publication
Longitudinal Change in Bone Density, Geometry, and Estimated Bone Strength in Older Men and Women From The Gambia: Findings From the Gambian Bone and Muscle Aging Study (GamBAS). J Bone Miner Res. Published 21 October 2022. doi:10.
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