Reference Values for Serum Calcium in Neonates Should Be Established in a Population of Vitamin D–Replete Subjects
Authors' conclusion
We show that the lower limit of the normal serum calcium range is higher in groups with a higher 25OHD than in unselected subjects. We propose that the reference range for serum calcium in neonates is 2.25 to 2.75 mmol/L.
Study context
- Population
- Mother-newborn pairs recruited April 2012–July 2014 in 2 centres near Paris, France, with serum calcium measured at 3 days of life
- Participants
- 1,002 / 514 / 202
- Exposure
- Neonates with cord blood 25OHD ≥30 nmol/L and ≥50 nmol/L vs whole cohort
- Whole populationn = 1,002reference
- 25OHD ≥ 30 nmol/Ln = 514
- 25OHD ≥ 50 nmol/Ln = 202
- Outcome
- Lower limit of the serum calcium normal range (95% range after exclusion of outliers)
- Follow-up
- 3 days of life
Methodological details2 centres
- 2 centres
Main finding
As reported in the abstract
Serum total calcium
| Group | Value | 95% CI |
|---|---|---|
| Whole | mean 2.46 ± 0.13 nmol/L | 2.19-2.72 mmol/L |
| 25OHD ≥ 30 nmol/L | mean 2.47 ± 0.25 mmol/L | 2.22-2.72 mmol/L |
| 25OHD ≥ 50 nmol/L | mean 2.50 ± 0.25 mmol/L | 2.25-2.75 mmol/L |
Value
Wholemean 2.46 ± 0.13 nmol/L
25OHD ≥ 30 nmol/Lmean 2.47 ± 0.25 mmol/L
25OHD ≥ 50 nmol/Lmean 2.50 ± 0.25 mmol/L
95% CI
Whole2.19-2.72 mmol/L
25OHD ≥ 30 nmol/L2.22-2.72 mmol/L
25OHD ≥ 50 nmol/L2.25-2.75 mmol/L
- 25OHD ≥ 30 nmol/L vs Whole: P < 0.05 — lower limit of 95% range significantly higher with 25OHD ≥ 30 nmol/L
- 25OHD ≥ 50 nmol/L vs Whole: P < 0.001 — lower limit of 95% range significantly higher with 25OHD ≥ 50 nmol/L
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Reference Values for Serum Calcium in Neonates Should Be Established in a Population of Vitamin D–Replete Subjects. J Clin Endocrinol Metab. Published 13 March 2024. doi:10.
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