Association of white matter hyperintensities with BMD, incident fractures, and falls in the UK Biobank cohort
Authors' conclusion
We demonstrated that a greater WMH was associated with BMD in an L-shaped dose-response manner, especially in women and those under 65 yr.
Study context
- Population
- UK Biobank participants with white matter hyperintensities (WMH) volume measured
- Participants
- 26,410 participants
- Exposure
- Higher vs lowest fifth of WMH volume
- Outcome
- Association of WMH volume with BMD, incident fractures and falls (dose-response)
- Follow-up
- Mean 3.8 yr
Methodological detailspopulation-based, UK Biobank
- Population-based
- UK Biobank
Main finding
As reported in the abstract
Reduction in femur neck BMD, second to highest fifths vs lowest
0.0102-0.0305 g/cm²
Reduction in femur troch BMD, second to highest fifths vs lowest
0.0075-0.0273 g/cm²
Reduction in LS BMD, second to highest fifths vs lowest
0.0173-0.0345 g/cm²
Reduction in total body BMD, second to highest fifths vs lowest
0.0141-0.0339 g/cm²
Observational data: associations, not effects.
Further findings
BMD association by subgroup (sex, age)
- Association more pronounced among women and participants under age 65
- P for interaction < 0.05
Incident hip fractures, all fractures and falls per 1 SD increment of WMH volume · mean follow-up 3.8 yr
- Hip fractures (events)
- 59
- All fractures (events)
- 392
- Falls (events)
- 375
- Higher risk of incident hip fractures per 1 SD WMH
- 36.9%
- Higher risk of all fractures per 1 SD WMH
- 20.1%
- Higher risk of falls per 1 SD WMH
- 14.3%
- Cox regression
Effect modification by genetically determined WMH or APOE genotype
- Genetically determined WMH or apolipoprotein E genotypes did not modify these associations
Original publication
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