Association Between Advanced Glycation End Products and Sarcopenia: The Mediating Role of Osteoporosis
Authors' conclusion
Elevated AGEs are associated with sarcopenia but not with presarcopenia. This association was partially mediated by osteoporosis.
Study context
- Population
- Community-dwelling older adults aged 72.37 ± 5.90 years from China; AGEs measured by AGE Reader, BMD by DXA
- Participants
- 1,991 adults
- Exposure
- Highest vs lowest AGE quartile
- Outcome
- Sarcopenia (loss of muscle mass plus loss of muscle strength and/or reduced physical performance)
Main finding
As reported in the abstract
Sarcopenia
Odds ratio (95% CI)P value
Highest AGE quartilevs Lowest AGE quartile
2.42(1.60–3.66)
P < 0.001for trendPer-SD increase in AGE
1.44(1.26–1.66)
- Prevalence of sarcopenia
- 18.5%
Observational data: associations, not effects.
Further findings
Osteoporosis prevalence
- Prevalence of osteoporosis
- 40.5%
Presarcopenia
- Highest AGE quartile not significantly associated with presarcopenia
Mediation by osteoporosis of AGE–sarcopenia association
- AGEs continuous: mediation effect Za*Zb
- 18.81 (95% CI 8.07-32.32)
- AGEs categorical: Zmediation
- 3.01
- Osteoporosis played a partial mediating role
Original publication
Association Between Advanced Glycation End Products and Sarcopenia: The Mediating Role of Osteoporosis. J Clin Endocrinol Metab. Published 31 October 2023. doi:10.
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