Relationships between longitudinal changes in body composition and bone mineral density in middle-to-older aged Australians
Authors' conclusion
∆LM is a stronger determinant than ∆FM of ∆BMD. Maintained or increased LM is associated with less age-related bone loss.
Study context
- Population
- Adults aged 46–70 years at baseline, Busselton Healthy Ageing Study, Australia; DXA at baseline and after ≈6 years2,019 females
- Participants
- 3,671 adults
- Exposure
- Changes in lean, fat and total body mass vs change in bone mineral density (BMD)
- Outcome
- ∆BMD at total hip, femoral neck and lumbar spine in relation to ∆TM, ∆LM and ∆FM
- Follow-up
- ≈6 years
Methodological detailslongitudinal, restricted cubic spline modelling, mid-quartile least square means
- Longitudinal
- Restricted cubic spline modelling
- Mid-quartile least square means
Main finding
As reported in the abstract
∆BMD by ∆LM
Difference in BMD reduction, women (all sites)
0.019-0.028 g/cm²
less reduction with Q4 (+1.6 kg) vs Q1 (−2.1 kg)
Difference in bone loss, men, total hip
0.015 g/cm²
less bone loss with Q4 (+1.6 kg) vs Q1 (−2.7 kg)
Difference in bone loss, men, femoral neck
0.011 g/cm²
less bone loss with Q4 (+1.6 kg) vs Q1 (−2.7 kg)
Observational data: associations, not effects.
Further findings
∆BMD by ∆TM · ≈6 years
- ∆TM positively associated with ∆BMD of total hip and femoral neck in both sexes, and spine in females; in females but not males, plateau above ∆TM ≈5kg
∆BMD by ∆FM · ≈6 years
- ∆FM positively associated with ∆BMD of total hip only, both sexes
Original publication
Relationships between longitudinal changes in body composition and bone mineral density in middle-to-older aged Australians. Osteoporos Int. Published 26 May 2023. doi:10.
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