Safety of Inpatient Zoledronic Acid in the Immediate Postfracture Setting
Authors' conclusion
IP-ZA along with standing multiple-doses-per-day acetaminophen, administered to patients in the immediate postfracture period, is not associated with significant acute adverse effects.
Study context
- Population
- Patients admitted to Massachusetts General Hospital with fragility fractures eligible to receive inpatient ZA (IP-ZA); acetaminophen (single pre-ZA dose or standing multiple doses/day ≥48 h) plus protocolized vitamin D and calcium
- Participants
- 285 consecutive patients
- Exposure
- Inpatient zoledronic acid vs no IP-ZA
- IP-ZAn = 204
- Outcome
- Acute safety: changes in body temperature, serum creatinine and serum calcium
Methodological detailssingle-centre, consecutive patients
- Single-centre
- Consecutive patients
Main finding
As reported in the abstract
Temperature >38 °C
- Transient mean rise of body temperature with IP-ZA on the day after administration
- 0.31 °C
- Mean serum total calcium decrease at nadir (Day 5)
- 0.54 mg/dL
- Mean albumin-corrected calcium decrease at nadir (Day 5)
- 0.40 mg/dL
Observational data: associations, not effects.
Safety
- Patients with symptomatic hypocalcemia
- 0
Original publication
Safety of Inpatient Zoledronic Acid in the Immediate Postfracture Setting. J Clin Endocrinol Metab. Published 25 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →