Twelve Loci Associated With Bone Density in Middle-aged and Elderly Chinese: The Shanghai Changfeng Study
Authors' conclusion
The present GWAS identified 12 loci that were significantly associated with BMD at any site in a Chinese population, and 3 of them showed sex differences in their effects.
Study context
- Population
- Middle-aged and elderly Chinese, Shanghai Changfeng Study; Bone mineral density (BMD) by DXA at lumbar spine and total and specific hip sites
- Participants
- 5,428 participants
- Outcome
- Associations between BMD and autosomal genetic variants, and sex differences
Methodological detailsmixed linear model, replication in Biobank Japan (BBJ)
- Mixed linear model
- Replication in Biobank Japan (BBJ)
Main finding
As reported in the abstract
Loci associated with BMD at any site
- Loci associated with BMD at any site (2 models)
- 12
Further findings
BMD loss by sex
- Women lost BMD at earlier ages and faster than men
Gene enrichment analysis
- BMD mainly related to ossification, bone resorption, sex hormones and kidney physiology
Original publication
Twelve Loci Associated With Bone Density in Middle-aged and Elderly Chinese: The Shanghai Changfeng Study. J Clin Endocrinol Metab. Published 13 October 2022. doi:10.
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