Is There a Causal Relationship between Physical Activity and Bone Microarchitecture? A Study of Adult Female Twin Pairs
Authors' conclusion
In conclusion, increasing PA was associated with thicker cortices, larger cortical area, lower porosity of the inner transitional zone, thicker trabeculae, and smaller medullary cavities. The attenuation of cross-pair cross-trait associations after accounting for the within-individual associations was consistent with PA having a causal effect on the improved cortical and trabecular microarchitecture of adult females, in addition to shared familial factors.
Study context
- Population
- Adult female twin pairs aged 31–77 years (47 dizygotic, 93 monozygotic); nondominant distal tibia imaged by HR-pQCT47 DZ and 93 MZ twin pairs
- Outcome
- Within-individual associations of PA index with distal tibia microarchitecture
Methodological detailstwin study, ICE FALCON
- Twin study
- ICE FALCON
Main finding
As reported in the abstract
- Cortical cross-sectional area (CSA), β (p < 0.05)
- 0.20
- Cortical thickness, β (p < 0.05)
- 0.22
- Porosity of inner transitional zone, β (p < 0.05)
- −0.17
- Trabecular volumetric bone mineral density (vBMD), β (p ≤ 0.01)
- 0.13
- Trabecular thickness, β (p ≤ 0.01)
- 0.14
- Medullary CSA, β (p ≤ 0.01)
- −0.22
Observational data: associations, not effects.
Further findings
Cross-pair cross-trait associations with physical activity (PA) after adjustment for within-individual association (ICE FALCON)
- Attenuation, cortical thickness (p for change)
- P = 0.048
- Attenuation, cortical CSA (p for change)
- P = 0.062
- Attenuation, medullary CSA (p for change)
- P = 0.028
Original publication
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