Cross-sectional studies of the causal link between asthma and osteoporosis: insights from Mendelian randomization and bioinformatics analysis
Authors' conclusion
Our study confirms a causal link between asthma and osteoporosis and highlights the importance of considering asthma in osteoporosis prediction models.
Study context
- Population
- Individuals in Chongqing, China, without a history of GC use, undergoing comprehensive health examinations
- Exposure
- Asthma vs no asthma
- Outcome
- Asthma and osteoporosis
Methodological detailsmulti-stage stratified random sampling, Mendelian randomization, bioinformatics analyses, logistic regression
- Multi-stage stratified random sampling
- Mendelian randomization
- Bioinformatics analyses
- Logistic regression
Main finding
As reported in the abstract
- Significant association between asthma and osteoporosis, suggesting a potential causal link
- Mendelian randomization analysis provided further support for this causal link
Observational data: associations, not effects.
Further findings
Mechanistic pathways
- Bioinformatics: several molecular pathways might mediate the impact of asthma on bone health
- Serum alkaline phosphatase significantly elevated in the asthma group
Original publication
Cross-sectional studies of the causal link between asthma and osteoporosis: insights from Mendelian randomization and bioinformatics analysis. Osteoporos Int. Published 2 March 2024. doi:10.
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