Assessment of causal association between the socio-economic status and osteoporosis and fractures: a bidirectional Mendelian randomization study in European population
Authors' conclusion
The MR analyses show that higher educational levels is associated with higher eBMD, reduced risk of osteoporosis and fractures, while material deprivation is positively related to spine fracture. Enhanced FN-BMD correlates with increased household income.
Study context
- Population
- Genome-wide association summary statistics of European ancestry
- Comparison
- Socio-economic status (SES) indicators vs BMD, osteoporosis and fractures, in both directions
- Outcome
- Causal associations between SES and bone outcomes
Methodological detailsinverse variance weighted method, MR-Egger, weighted median and MR-PRESSO, sensitivity analyses, multivariable Mendelian randomization (MR), adjusted for BMI, T2D, smoking initiation and frequency of alcohol intake
- Inverse variance weighted method
- MR-Egger, weighted median and MR-PRESSO
- Sensitivity analyses
- Multivariable MR
- Adjusted for BMI, T2D, smoking initiation and frequency of alcohol intake
Main finding
As reported in the abstract
- Higher educational attainment and eBMD, β (95% CI 0.01-0.10; P = 7.24 × 10-3)
- .06
- Higher educational attainment and osteoporosis, OR
- 0.78 (95% CI 0.65-0.94; P = 8.49 × 10-3)
- Higher educational attainment and spine fracture, OR
- 0.76 (95% CI 0.66-0.88; P = 2.94 × 10-4)
- Higher educational attainment and femur fracture, OR
- 0.78 (95% CI 0.67-0.91; P = 1.33 × 10-3)
- Higher educational attainment and lower leg-ankle fracture, OR
- 0.79 (95% CI 0.70-0.88; P = 2.05 × 10-5)
- Higher educational attainment and foot fracture, OR
- 0.78 (95% CI 0.66-0.93; P = 5.92 × 10-3)
- Higher educational attainment and wrist-hand fracture, OR
- 0.83 (95% CI 0.73-0.95; P = 7.15 × 10-3)
- Material deprivation and spine fracture, OR
- 2.63 (95% CI 1.43-4.85; P = 1.91 × 10-3)
- Higher femoral neck bone mineral density (FN-BMD) and increased household income, β (95% CI 0.01-0.04; P = 6.78 × 10-3)
- .03
Original publication
Assessment of causal association between the socio-economic status and osteoporosis and fractures: a bidirectional Mendelian randomization study in European population. J Bone Miner Res. Published 16 April 2024. doi:10.
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