Shared genetic basis connects smoking behaviors and bone health: insights from a genome-wide cross-trait analysis
Authors' conclusion
Our study demonstrates a pronounced biological pleiotropy as well as a putative causal link between current smoking status and eBMD
Study context
- Population
- European-ancestry GWAS: smoking initiation (Nsmoker = 1,175,108, Nnonsmoker = 1,493,921), heaviness (cigarettes per day, N = 618,489), cessation (Ncurrent smoker = 304,244, Nformer smoker = 843,028), and estimated bone mineral density (eBMD)GWAS summary statistics · eBMD 426,824
- Comparison
- Smoking behaviours vs heel eBMD
- Outcome
- Shared genetic architecture of smoking and eBMD
Methodological detailsGWAS summary statistics, European ancestry, genetic correlation, cross-trait meta-analysis
- GWAS summary statistics
- European ancestry
- Genetic correlation
- Cross-trait meta-analysis
Pooled result
As reported in the abstract
Global genetic correlation, smoking cessation and eBMD (significant negative)
rg = −0.051
P = 0.01
Significant shared local signals for smoking and eBMD; 22q13.1 strongest regional genetic correlation
6
Pleiotropic loci in cross-trait meta-analysis
71
Further pooled results
MR: causal effect of smoking on eBMD
| Beta (g/cm²) (95% CI) | |
|---|---|
| Smoking initiationNo causal effect | −0.003 (−0.033 to 0.027) |
| Smoking heavinessNo causal effect | −0.017 (−0.072 to 0.038) |
| Outcome | Beta (g/cm²) (95% CI) |
|---|---|
| MR: causal effect of smoking on eBMDCurrent smoker vs Former smokers | −0.100 (−0.181 to −0.018) |
- MR: causal effect of smoking on eBMD: putative causal effect; lower eBMD with genetic predisposition to current smoking
Original publication
Shared genetic basis connects smoking behaviors and bone health: insights from a genome-wide cross-trait analysis. J Bone Miner Res. Published 6 June 2024. doi:10.
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