Causal associations of osteoporosis with stroke: a bidirectional Mendelian randomization study
Authors' conclusion
In conclusion, there is a causal relationship between stroke and OP, suggesting that they may be potential risk factors for each other.
Study context
- Population
- European populations: Osteoporosis (OP) genome-wide association studies (GWAS) from FinnGen consortium; stroke GWAS from MEGASTROKE consortium
- Comparison
- Genetically predicted stroke (and subtypes) on OP, and genetically predicted OP on stroke (and subtypes)
- Outcome
- Causal relationship between OP and stroke
Methodological detailstwo-sample, GWAS summary data, inverse variance weighted, MR-Egger and weighted median
- Two-sample
- GWAS summary data
- Inverse variance weighted, MR-Egger and weighted median
Main finding
As reported in the abstract
Odds ratio (95% CI)P value
Strokestroke on OP
1.39(1.04–1.85)
P = 0.027ISIS on OP
2.02(1.05–3.87)
P = 0.035LASLAS on OP
1.29(1.08–1.55)
P = 0.005OPOP on SVS
1.08(1.01–1.14)
P = 0.021Further findings
OP with pathological fracture
| OR (95% CI) | P value | ||
|---|---|---|---|
| LASLAS on OP with pathological fracture | 1.69 (1.18–2.42) | P = 0.004 | |
| 0.512Odds ratio (log scale) |
Postmenopausal OP with pathological fracture
| OR (95% CI) | P value | ||
|---|---|---|---|
| StrokeStroke on postmenopausal OP with pathological fracture | 2.02 (1.05–3.87) | P = 0.035 | |
| LASLAS on postmenopausal OP with pathological fracture | 1.75 (1.06–2.90) | P = 0.030 | |
| 0.20.5125Odds ratio (log scale) |
Original publication
Causal associations of osteoporosis with stroke: a bidirectional Mendelian randomization study. Osteoporos Int. Published 24 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →