Corticosteroid rhythms in hypoparathyroid patients
Authors' conclusion
Adrenocortical hormone levels are reduced in postsurgical hypoparathyroidism, and partly restored by short-term continuous subcutaneous PTH (1-34) therapy.
Study context
- Population
- Patients with postsurgical hypoparathyroidism with very low parathyroid hormone (PTH) levels on stable treatment with active vitamin D and calcium
- Comparison
- Continuous subcutaneous PTH (1-34) infusion vs before infusion in postsurgical hypoparathyroidism; hypoparathyroid patients vs PHPT patients and healthy controls
- Outcome
- Adrenocortical secretion: cortisol, cortisone and aldosterone in subcutaneous tissue microdialysate
- Follow-up
- Over 24 h, before and during PTH (1-34) infusion
Main finding
As reported in the abstract
Tissue cortisol, cortisone and aldosterone
- Hypoparathyroid patients displayed both ultradian and circadian rhythmicity for tissue cortisol, cortisone and aldosterone
- Tissue aldosterone and cortisone significantly lower in hypoparathyroid patients than healthy controls
- No difference in tissue cortisol vs healthy controls, but higher cortisol to cortisone ratio
- PTH (1-34) increased tissue aldosterone, cortisol and cortisone and reduced cortisol to cortisone ratio
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Corticosteroid rhythms in hypoparathyroid patients. Eur J Endocrinol. Published 21 August 2024. doi:10.
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