Pilot Study of Plasma miRNA Signature Panel for Differentiating Single vs Multiglandular Parathyroid Disease
Authors' conclusion
Twenty-seven miRs were consistently found DE in single-PTA tissue and plasma samples. Data integration showed a 9-cfmiR signature with potential clinical utility to preoperatively diagnose sPHPT caused by a single PTA, which could decrease more invasive parathyroid explorations.
Study context
- Population
- Patients with sporadic PHPT (sporadic primary hyperparathyroidism (sPHPT)); preoperative plasma from 16 single-PTA patients and 29 normal healthy donors (NHDs)47 sPHPT
- Participants
- 32 / 12 / 9 / 29
- Comparison
- Tissue and plasma miRNA signatures in single-PTA vs double-PTA, MGD and normal parathyroid/NHDs
- Single-PTAn = 32
- Double-PTAn = 12
- MGDn = 9
- NHDsn = 29reference
- Outcome
- Receiver operating characteristic curves and areas under the curve
Methodological detailspilot study
- Pilot study
Performance
As reported in the abstract
miRNAs/cfmiRs DE in both tissue and plasma from single-PTA patients
miRNAs/cell-free miRNA (cfmiRs) differentially expressed (DE) both in tissue and plasma in single parathyroid adenoma (PTA)
9
AUC
76%
Further findings
Tissue miRNA (miR) signatures
- miR signature in single-PTA tissue vs rest of tissue samples
- 27-miR
- MiR signatures distinguished normal parathyroid from MGD and PTA, and MGD from PTA in tissue
- Common miRs in single-PTA and double-PTAs
Plasma cfmiRs, single-PTA vs NHD
- Significant cfmiRs were DE in single-PTA patients vs NHD
Original publication
Pilot Study of Plasma miRNA Signature Panel for Differentiating Single vs Multiglandular Parathyroid Disease. J Clin Endocrinol Metab. Published 20 August 2024. doi:10.
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