Nephrocalcinosis and kidney function in children and adults with X-linked hypophosphatemia: baseline results from a large longitudinal study
Authors' conclusion
Nephrocalcinosis was observed in nearly one-quarter of children and more than one-third of adults with XLH. Further study is needed to better understand the predictors and long-term consequences of nephrocalcinosis, with surveillance for nephrocalcinosis remaining important in the management of XLH.
Study context
- Population
- Burosumab-naïve patients with X-linked hypophosphatemia (XLH) in burosumab clinical trials or the XLH Disease Monitoring Program (XLH-DMP); nearly all previously received conventional therapy (oral phosphate salts and active vitamin D)
- Participants
- 196 vs 318
- Exposure
- Patients with vs without nephrocalcinosis
- Childrenn = 196
- Adultsn = 318
- Outcome
- Nephrocalcinosis on renal US
- Follow-up
- Baseline
Methodological detailsbaseline analysis of burosumab clinical trials and XLH Disease Monitoring Program
- Baseline analysis of burosumab clinical trials and XLH Disease Monitoring Program
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Reduced eGFR <90 mL/min/1.73 m² by nephrocalcinosis · baseline
- Children with nephrocalcinosis
- 25%
- Children without nephrocalcinosis
- 11%
- Higher prevalence with nephrocalcinosis not observed in adults
Laboratory values in children with vs without nephrocalcinosis · baseline
- Lower mean TmP/GFR with nephrocalcinosis
- P < 0.05
- Lower mean eGFR with nephrocalcinosis
- P < 0.001
- Higher mean serum calcium with nephrocalcinosis
- P < 0.05
Laboratory values in adults with vs without nephrocalcinosis · baseline
- Lower mean serum phosphorus with nephrocalcinosis
- P < 0.01
Exploratory logistic regression: nephrocalcinosis vs other patient or disease characteristics
- No significant associations
- Exploratory
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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