Accelerated Bone Loss in Older Men With Severe Abdominal Aortic Calcification—the Prospective MINOS Study
Authors' conclusion
Severe AAC is associated with faster bone loss in older men and may contribute to the higher fracture risk observed in this population.
Study context
- Population
- Men aged 50 to 85 years (MINOS), abdominal aortic calcification (AAC) assessed on lateral spine radiograph, followed 7.5 years
- Participants
- 778 men
- Exposure
- Severe AAC vs no AAC
- Outcome
- Bone loss (BMD and BMC by DXA every 18 months)
- Follow-up
- 7.5 years
Methodological detailsLinear mixed models
- Linear mixed models
Main finding
As reported in the abstract
Bone loss, total hip
Severe AAC
−0.62
± 0.06 · %/year
No AAC
−0.32
± 0.04 · %/year
P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Severe AAC | Highest decile | No AAC | P value |
|---|---|---|---|---|
| Bone loss, distal forearmSevere AAC vs No AAC | −0.72 ± 0.06 %/year | — not stated in the abstract | −0.45 ± 0.03 %/year | P < 0.001 |
| Bone loss, ultradistal radiusHighest decile vs No AAC · more rapid bone loss also at femoral neck and whole body | — not stated in the abstract | −0.86 ± 0.12 %/year | −0.34 ± 0.05 %/year | P < 0.001 |
— not stated in the abstract
Bone mineral density (BMD) vs bone mineral content (BMC); sensitivity analyses
- Results similar for BMD and for BMC
- Patterns similar in sensitivity analyses (eg, excluding abdominal obesity, current smokers, ischemic heart disease or DM, abnormal lipids, bioavailable 17β-estradiol or 25-hydroxycholecalciferol, GFR <60 mL/min)
Original publication
Accelerated Bone Loss in Older Men With Severe Abdominal Aortic Calcification—the Prospective MINOS Study. J Clin Endocrinol Metab. Published 23 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →