The Role of Circulating Secreted Frizzled-Related Protein 4 (SFRP4) in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
Pooled result · Circulating SFRP4 levelsResult — go to the resultSMD 1.70 95% CI 0.47–2.94Authors' conclusion
Elevated circulating SFRP4 levels are associated with T2DM and may represent a promising researchbiomarker.
Study context
- Population
- Adults with T2D and healthy controls in observational studies9 studies in meta-analysis
- Participants
- 631 vs 467
- Comparison
- Circulating SFRP4 levels in T2D vs healthy controls
- T2DMn = 631
- Controlsn = 467reference
- Outcome
- Circulating SFRP4 levels
Methodological detailsrandom-effects model, PRISMA, 12 studies in systematic review; quality assessed with Newcastle-Ottawa Scale and Joanna Briggs Institute checklist
- Random-effects model
- PRISMA
- 12 studies in systematic review; quality assessed with Newcastle-Ottawa Scale and Joanna Briggs Institute checklist
Pooled result
As reported in the abstract
SMD
1.70
95% CI 0.47–2.94
P = 0.0131
T2DMvs Controls
SMD 1.70 (95% CI 0.47–2.94); P = 0.0131
Further pooled results
- Sensitivity analyses supported the robustness of the findings
Original publication
The Role of Circulating Secreted Frizzled-Related Protein 4 (SFRP4) in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. Diabetes Res Clin Pract. Published 18 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →