Association Between Circulating Levels of C1q/TNF-Related Protein-9 and Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis
Pooled result · Circulating CTRP9Result — go to the resultSMD −1.36 95% CI −1.78 to −0.93Authors' conclusion
The present systematic review and meta-analysis found CTRP9 levels were lower in T2DM patients with or without complications. However, since this was a meta-analysis of most observational studies, these findings still need to be verified by further studies with a large sample size.
Study context
- Population
- Adults ≥18 years with clinically diagnosed T2D, with or without complications; studies until October 31, 2021
- Comparison
- Circulating CTRP9 in T2D vs no diabetes; T2D with vs without complications
- Outcome
- Circulating level of CTRP9
Pooled result
Circulating CTRP9
SMD
−1.36
95% CI −1.78 to −0.93
P < 0.001
T2Dvs No diabetes
SMD −1.36 (95% CI −1.78 to −0.93); P < 0.001
As reported in the abstract
Further pooled results
| Outcome | SMD (95% CI) | P value | |
|---|---|---|---|
| Circulating CTRP9: T2DM withvs without complications (macrovascular or microvascular)I2 = 91.3%, P < .001 | −1.062 (−1.466 to −0.658) | P < 0.001 | |
| −2−101Difference (linear scale) |
Subgroup analyses: sources of heterogeneity
- BMI
- P = 0.047
- T2DM duration
- P = 0.034
- Fasting blood glucose
- P = 0.07
Original publication
Association Between Circulating Levels of C1q/TNF-Related Protein-9 and Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis. J Clin Endocrinol Metab. Published 8 April 2023. doi:10.
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