The association of fetal growth rate and growth in first year of life with childhood overweight: a cohort study
Main finding · Overweight at age 5-9 yearsResult — go to the resultOdds ratio 1.52 95% CI 1.20–1.90Authors' conclusion
Fetal and infant growth were independently associated with overweight, but distinct combinations of fetal and infant growth showed marked differences in risk. Infant, but not fetal, growth improved a prediction model containing known confounders.
Study context
- Population
- Children with fetal growth data from Aarhus University Hospital and child growth data from Aarhus Municipality, 2008–2018
- Participants
- 6,206 children
- Exposure
- Fetal growth rate and infant growth patterns vs childhood overweight
- Outcome
- Overweight at age 5-9 years
- Follow-up
- Age 5-9 years
Methodological detailsroutinely collected data, mixed models, latent class analysis
- Routinely collected data
- Mixed models
- Latent class analysis
Main finding
As reported in the abstract
Odds ratio
1.52
95% CI 1.20–1.90
Acceleratedvs Average
OR 1.52 (95% CI 1.20–1.90)
- OR of overweight per 10 g/week increase in fetal growth rate at week 34
- 1.09 (95% CI: 1.06-1.12)
- Average fetal growth with accelerated infant growth
- OR 1.96 (95% CI: 1.41-2.73)
- Fast fetal growth with decelerated infant growth: not associated with overweight
- OR 0.79 (95% CI: 0.63-0.98)
Observational data: associations, not effects.
Further findings
Prediction of overweight (AUCROC) added to model with known risk factors
- Infant growth added: AUCROC difference
- 0.04 (95% CI: 0.03-0.06)
- Fetal growth added: AUCROC unchanged
Original publication
The association of fetal growth rate and growth in first year of life with childhood overweight: a cohort study. Int J Obes (Lond). Published 21 September 2024. doi:10.
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