In which common chronic conditions can (or cannot) obesity and lifestyle factors explain higher concentrations of C‐reactive protein?
Authors' conclusion
In diabetes, MI, hypertension and sleep apnoea and elevated CRP appears to be accounted for by the greater adiposity typically evident in these conditions. However, for the other conditions, systemic inflammation cannot be explained by excess adiposity alone.
Study context
- Population
- UK Biobank participants with 10 chronic conditions reported at baseline, excluding potential acute infection
- Participants
- 292,772 participants
- Exposure
- Chronic conditions vs without the condition; C-reactive protein (CRP) unadjusted and adjusted for sociodemographic confounders, lifestyle, body mass index (BMI) and adiposity
- Outcome
- CRP concentration (lnCRP) in each chronic condition, unadjusted and adjusted
- Follow-up
- Baseline
Main finding
As reported in the abstract
CRP concentration by chronic condition
Diabetes vs without diabetes, unadjusted: higher CRP
42%
Diabetes vs without diabetes, unadjusted: lnCRP β
0.35
95% CI 0.32–0.37p < 0.001
Diabetes vs without diabetes, BMI-adjusted: lnCRP β (95% CI −0.09-0.05, p < 0.001); completely attenuated
−0.07
Observational data: associations, not effects.
Original publication
In which common chronic conditions can (or cannot) obesity and lifestyle factors explain higher concentrations of C‐reactive protein? Diabetes Obes Metab. Published 20 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →