Effects of Mediterranean diet during pregnancy on the onset of overweight or obesity in the offspring: a randomized trial
An erratum to this article was published (Int J Obes (Lond), Jan 2025 ↗)
Primary result · Offspring overweight or obesityResult — go to the resultAbsolute risk difference −24% 95% CI −38% to −9%Authors' conclusion
MD during pregnancy could be an effective strategy for preventing pediatric overweight or obesity at 24 months. This effect involves, at least in part, an epigenetic modification of leptin expression.
Study context
- Population
- Women in their first trimester of pregnancy97 completed
- Participants
- 104 women
- Comparison
- Nutritional counseling promoting Mediterranean diet (MD) during pregnancy vs standard care (CT)
- Primary endpoint
- Proportion of overweight or obesity among the offspring
- Follow-up
- 24 months of age
Methodological detailsparallel-arm, Lost to follow-up: 5 in MD, 2 in CT
- Parallel-arm
- Lost to follow-up: 5 in MD, 2 in CT
Primary result
Offspring overweight or obesity · 24 months
Absolute risk difference
−24%
95% CI −38% to −9%
P = 0.003
By group
MDvs CT
absolute risk difference −24% (95% CI −38% to −9%); P = 0.003
As reported in the abstract
- NNT
- 4 (95% CI 2 to 12)
Further findings
Leptin gene methylation rate in cord blood
P < 0.0001
Increase of maternal MD-adherence · during the trial
- Significantly higher increase in MD vs CT
Maternal body weight gain · end of pregnancy
- Similar in the two arms
Original publication
Effects of Mediterranean diet during pregnancy on the onset of overweight or obesity in the offspring: a randomized trial. Int J Obes (Lond). Published 18 September 2024. doi:10.
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