Weight Loss Intervention Promoting an Adapted Mediterranean-Style Dietary Pattern: The DELISH Randomized Clinical Trial
Primary result · Adjusted mean percentage change in body weightResult — go to the resultDifference −0.11 95% CI −1.79 to 1.57Authors' conclusion
In this randomized clinical trial comparing a Mediterranean-style weight loss intervention to a control intervention, there was no material difference in percentage change in body weight at the 24-month follow-up visit between participants in these programs.
Study context
- Population
- Adults aged 18 to 75 years with BMI ≥30, from 1 academic and 6 community primary care practices in central North Carolina; mean age 54.7 years, 55.6% female
- Participants
- 360 adults
- Comparison
- Mediterranean-style weight loss program vs control weight loss program
- Mediterranean-stylen = 182
- Controln = 178reference
- Primary endpoint
- Percentage change in body weight
- Follow-up
- 24 months
Methodological detailsmulticentre, 24-month follow-up attended by 118 (64.8%) Mediterranean-style and 129 (72.5%) control
- Multicentre
- 24-month follow-up attended by 118 (64.8%) Mediterranean-style and 129 (72.5%) control
Primary result
Adjusted mean percentage change in body weight
Difference
−0.11
95% CI −1.79 to 1.57
P = 0.90
Change by group
Mediterranean-style
−3.40
adjusted mean · SE 0.60% · %
Control
−3.51
adjusted mean · SE 0.66% · %
Controlvs Mediterranean-style
difference −0.11 (95% CI −1.79 to 1.57); P = 0.90
As reported in the abstract
Secondary outcomes
| Outcome | Difference (95% CI) | P value | |
|---|---|---|---|
| Alternative Healthy Eating Index-2010 score (participants who returned for follow-up) | 3.62 (1.11–6.12) | P = 0.005 | |
| −50510Difference (linear scale) |
Original publication
Weight Loss Intervention Promoting an Adapted Mediterranean-Style Dietary Pattern: The DELISH Randomized Clinical Trial. JAMA Netw Open. Published 3 August 2026. doi:10.
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