Lipid profiling identifies modifiable signatures of cardiometabolic risk in children and adolescents with obesity
Authors' conclusion
The nonpharmacological management reduced levels of ceramides, phospholipids and triglycerides, indicating that lowering the degree of obesity could partially restore a healthy lipid profile in children and adolescents.
Study context
- Population
- Children and adolescents with overweight or obesity and with normal weight186 in management program
- Participants
- 958 vs 373
- Exposure
- Overweight or obesity vs normal weight; before vs after nonpharmacological obesity management
- Overweight or obesityn = 958
- Normal weightn = 373reference
- Outcome
- Peripheral lipidome with obesity
Methodological detailsmass spectrometry-based lipidomics, family-based personalized obesity management program
- Mass spectrometry-based lipidomics
- Family-based personalized obesity management program
Main finding
As reported in the abstract
- Increase in ceramides, decrease in lysophospholipids and omega-3 fatty acids with obesity metabolism
- Ceramides, phosphatidylethanolamines and phosphatidylinositols associated with insulin resistance and cardiometabolic risk; sphingomyelins inversely associated
- A panel of three lipids predicted hepatic steatosis as effectively as liver enzymes
- Lipids partially mediated the association between obesity and cardiometabolic traits
Observational data: associations, not effects.
Further findings
Effect of nonpharmacological obesity management on lipids
- Management reduced levels of ceramides, phospholipids and TG
Original publication
Lipid profiling identifies modifiable signatures of cardiometabolic risk in children and adolescents with obesity. Nat Med. Published 20 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →