Sustained 3-Year Improvement of Glucose Control With Hybrid Closed Loop in Children With Type 1 Diabetes While Going Through Puberty
Authors' conclusion
Prolonged use of HCL can safely and effectively mitigate impairment of glucose control usually associated with pubertal progression without impact on BMI in children with T1D.
Study context
- Population
- Children with T1D, prepubertal (aged 6–12 years) at FLKAP entry, using HCL through pubertal progression; mean age 10.1 years (6.8–14.0) at extension startcompleted extension
- Participants
- 117 children
- Comparison
- HbA1c and BMI z score at M39/M24 vs M9 with continued HCL
Methodological detailsmulticenter, noninferiority tests
- Multicenter
- Noninferiority tests
Primary result
As reported in the abstract
HbA1c · M9 vs M39
P < 0.0001 for noninferiority test
Further findings
| Outcome | M9 | M39 | P value |
|---|---|---|---|
| BMI z score · M9 vs M24Value at M24 | 0.41 (IQR −0.29–1.13) | 0.48 (IQR −0.11–1.13) | P < 0.0001, for noninferiority test |
- BMI z score: later value measured at M24
HbA1c by pubertal status at M24 (Tanner stage ≥2 vs prepubertal)
- Entered puberty at M24
- 54%
- HbA1c did not differ between children who entered puberty at M24 and those who remained prepubertal
Safety
- Ketoacidosis episode not related to the HCL system
- one
- No severe hypoglycemia occurred
Original publication
Sustained 3-Year Improvement of Glucose Control With Hybrid Closed Loop in Children With Type 1 Diabetes While Going Through Puberty. Diabetes Care. Published 10 July 2024. doi:10.
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