Liver fibrosis and liver stiffness in patients with obesity and type 1 diabetes
Main finding · Liver stiffnessResult — go to the resultOdds ratio 5.4 95% CI 2.1–13.6Authors' conclusion
Patients with obesity and T1D had lower liver fat and liver stiffness compared with those patients with T2D, despite similar levels of BMI, a longer duration of diabetes and worse glycaemic control.
Study context
- Population
- Patients with obesity and T1D or T2D with similar body mass index (BMI); liver fat fraction by MRI and stiffness by elastography
- Participants
- 90 vs 69
- Exposure
- T1D vs T2D with similar BMI, in patients with obesity
- T1Dn = 90
- T2Dn = 69reference
- Outcome
- Hepatic stiffness and fat fraction
Methodological detailsprospective
- Prospective
Main finding
Liver stiffness
Odds ratio
5.4
95% CI 2.1–13.6
P < 0.001
By group
T2Dvs T1D
OR 5.4 (95% CI 2.1–13.6); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
Liver fat fraction
P < 0.001
MASLD
Fibrosis suggested
Associations with liver fat and stiffness
- Aspartate transaminase (AST), ALT, gamma-glutamyl transferase (GGT), TG and android-to-gynoid ratio associated with elevated fat fraction in both cohorts
- AST and GGT associated with elevated liver stiffness in both cohorts
Original publication
Liver fibrosis and liver stiffness in patients with obesity and type 1 diabetes. Diabetes Obes Metab. Published 10 July 2024. doi:10.
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