Characterising impaired awareness of hypoglycaemia and associated risks through Hypoglycaemia Awareness Questionnaire (HypoA-Q): findings from a T1D Exchange cohort
Authors' conclusion
The HypoA-Q IA is a brief, valid and reliable tool for assessing IAH in today's technology-oriented era. IAH was independently associated with severe hypoglycaemia and level 2 hypoglycaemia in a cohort with high prevalence of advanced diabetes technology use and HbA1c within the recommended range. CGM and HCL use was related to lower IAH risk.
Study context
- Population
- Adults with T1D, T1D Exchange registrants; median age 44 years, 52% female, median HbA1c 48 mmol/mol [6.5%]; 94% using continuous glucose monitor (CGM), 69% hybrid closed-loop (HCL)
- Participants
- 1,580 valid survey responses
- Outcome
- HypoA-Q IA validation and IAH associations
Methodological detailsnationwide survey, T1D Exchange registrants, external validation
- Nationwide survey
- T1D Exchange registrants
- External validation
Main finding
As reported in the abstract
- HypoA-Q IA internal reliability (Cronbach's α)
- 0.79
- Higher HypoA-Q IA scores independently associated with greater risk of severe hypoglycaemia, comparable to Gold and Clarke hypoglycaemia awareness factor (Clarke-HAF) instruments
- p<0.001
- HypoA-Q IA-determined impaired awareness of hypoglycaemia (IAH): 88% higher odds of severe hypoglycaemia
- p<0.001
- HypoA-Q IA-determined IAH: twofold higher odds of ≥1% time in level 2 hypoglycaemia
- p=0.011
Observational data: associations, not effects.
Further findings
Severe hypoglycaemia in past 6 months
- ≥1 severe-hypoglycaemia episode
- 30%
Factors associated with IAH
- Higher age and longer diabetes duration associated with higher IAH risk
- P < 0.001
- CGM and HCL use associated with lower IAH risk
- P < 0.001
Original publication
Characterising impaired awareness of hypoglycaemia and associated risks through HypoA-Q: findings from a T1D Exchange cohort. Diabetologia. Published 30 October 2024. doi:10.
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