Gestational diabetes & diabetes in pregnancy
Short-term modulation of human milk oligosaccharides in plasma and milk by glucose and insulin: insights into postpartum metabolic regulation
Authors' conclusion
Circulating HMOs persist during lactation and are acutely regulated by glucose and insulin.
Study context
- Population
- Women at 5–7 weeks postpartum (16 with prior GDM; 18 breastfeeding)
- Participants
- 28 women
- Outcome
- Circulating HMOs postpartum, their short-term modulation by glucose and insulin, and relationship between plasma and milk HMO profiles
- Follow-up
- 5-7 weeks postpartum
Methodological detailsOral glucose tolerance test (OGTT) and hyperinsulinaemic-euglycaemic clamp
- OGTT and hyperinsulinaemic-euglycaemic clamp
Main finding
As reported in the abstract
Human milk oligosaccharides (HMOs) detected in milk
17
HMOs also detected in plasma, at concentrations ≈10,000-fold lower but highly correlated across compartments
6
Original publication
Short-term modulation of human milk oligosaccharides in plasma and milk by glucose and insulin: insights into postpartum metabolic regulation. Diabetologia. Published 17 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →