Severity of thyrotoxicosis is a risk factor for excessive weight gain in treated hyperthyroidism
Authors' conclusion
More than half the patients with hyperthyroidism had ≥10% PWG post-treatment. Indicators of disease severity, namely disease-related weight loss and baseline thyroid hormones, were predictive of excessive weight gain post-treatment and could be utilized for risk stratification and early intervention.
Study context
- Population
- Patients with hyperthyroidism 6–36 months after treatment initiation; 73 (66.4%) women
- Participants
- 110 patients
- Exposure
- Percentage weight gain (PWG) ≥10% vs <10%
- Outcome
- Peak percentage weight gain (PWG) ≥10% vs <10% post-treatment
- Follow-up
- 6-36 months after treatment initiation
Main finding
As reported in the abstract
Disease-related weight loss, OR
1.23
P = 0.002
fT4 at diagnosis, OR
1.04
P = 0.008
Proportion with PWG ≥10% (group A)
52.7%
Observational data: associations, not effects.
Further findings
fT4 at diagnosis · higher in group A
P < 0.001
Disease-related weight loss · higher in group A
P < 0.001
Free triiodothyronine at presentation · non-significantly higher in group A
P = 0.078
TRAb at presentation · non-significantly higher in group A
P = 0.093
Weight change
kg
- Post-treatment weight gain, mean (SD)
- 7.4 (5.22)
- Disease-related weight loss, mean (SD)
- 5.3 (5.15)
Original publication
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