Efficacy and Safety of Adjunctive Bile Acid Sequestrant Therapy for Thyrotoxicosis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors' conclusion
Adjunctive bile acid sequestrants with standard hyperthyroidism therapy appear to enhance reductions in serum total T3 and free T4 at the mark of four weeks and were well tolerated. However, due to considerable heterogeneity and low quality of evidence, our results should be interpreted with caution. Larger, high-quality RCTs are needed to strengthen the evidence regarding the efficacy of adjunctive bile acid sequestrant therapy.
Study context
- Population
- Adult non-critically ill patients with hyperthyroidism (Graves' disease, toxic adenoma, multinodular goiter)
- Participants
- 173 patients5 randomized controlled trials (RCTs)
- Comparison
- Standard therapy plus adjunctive bile acid sequestrants vs standard therapy alone
- Adjunctive bile acid sequestrantsn = 93
- Standard therapyn = 80reference
- Outcome
- Reduction in serum FT4 and total T3
Pooled result
As reported in the abstract
Total T3, adjunctive bile acid sequestrants vs standard therapy alone: MD (95% CI) — statistically significant reduction
−1.59 nmol/L
−2.90 to −0.27
Free T4, adjunctive bile acid sequestrants vs standard therapy alone: MD (CI) — statistically significant reduction
−1 ng/dL
−1.74 to −0.25
Further pooled results
| Outcome | MD (nmol/L) (95% CI) | |
|---|---|---|
| Reduction in serum total T3 and free T4 · 2 weeksBile acid sequestrantsvs Standard therapyTotal T3; non-significant reduction | −0.44 (−1.2 to +0.32) | |
| −1.5−1−0.500.5Difference, nmol/L (linear scale) |
| Outcome | MD (ng/dL) (95% CI) | |
|---|---|---|
| Reduction in serum total T3 and free T4 · 2 weeksBile acid sequestrantsvs Standard therapyFree T4; non-significant reduction | −0.55 (−1.15 to +0.04) | |
| −1.5−1−0.500.5Difference, ng/dL (linear scale) |
Safety
Tolerability
- Adjunctive bile acid sequestrants were well tolerated
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →