Iopanoic acid rapidly restores euthyroidism in refractory thyrotoxicosis pre-thyroidectomy: a retrospective study
Authors' conclusion
IOPA is a safe and effective agent for controlling biochemical thyrotoxicosis in preparation for thyroidectomy, including disease refractory to conventional medication. Highly pure, laboratory-grade iopanoic acid that is approved for human use is now available in the UK; consideration should be given to more widespread use for emergency treatment of life-threatening hyperthyroidism.
Study context
- Population
- Patients with ongoing, severe thyrotoxicosis with inadequate response to standard therapies, prior to thyroidectomy; aetiologies included GD, amiodarone-induced thyrotoxicosis, toxic multinodular goitre and resistance to thyroid hormone beta
- Participants
- 12 patients
- Outcome
- FT3 decrease
Methodological detailssingle referral centre
- Single referral centre
Main finding
As reported in the abstract
All patients had a decline and normalization/near-normalization of free T3 (FT3) (mean decrease, SEM)
55%
SEM 4.5%
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Uneventful thyroidectomy | IOPA 11 events |
Safety
Safety and tolerability
- Proceeded to uneventful thyroidectomy
- Eleven patients
- Iopanoic acid (IOPA) was well tolerated with no directly attributable side effects
Original publication
Iopanoic acid rapidly restores euthyroidism in refractory thyrotoxicosis pre-thyroidectomy: a retrospective study. Eur Thyroid J. Published 25 February 2026. doi:10.
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