Major adverse cardiac events in patients with amiodarone-induced thyrotoxicosis undergoing thyroidectomy: a multicenter study
Authors' conclusion
Patients with LVEF < 40% carries a high long-term CV risk despite early thyroidectomy. Post-operative LVEF assessment may help identify high-risk patients. In contrast, those with LVEF ≥ 40% have a favorable prognosis.
Study context
- Population
- Patients undergoing total thyroidectomy for amiodarone-induced thyrotoxicosis (AIT), 2010–2023, two French referral centers
- Participants
- 101 patients
- Exposure
- Pre-operative left ventricular ejection fraction (LVEF) <40% vs ≥40% in AIT patients undergoing total thyroidectomy
- Group 1n = 26
- Group 2n = 75reference
- Outcome
- Post-operative major adverse cardiovascular events (MACEs) and cardiac mortality
- Follow-up
- One and five years
Methodological detailsmulticentre, two French referral centers
- Multicentre
- Two French referral centers
Main finding
As reported in the abstract
5 years
- Group 1 vs Group 2: P = 0.0005
- Group 1 vs Group 2: P = 0.0001
Observational data: associations, not effects.
Further findings
5-year MACE in LVEF < 40% subgroup, by early post-operative LVEF improvement · lower with early LVEF improvement
P = 0.022
Factors associated with 5-year MACE (multivariate regression)
- Younger age at AIT diagnosis and baseline LVEF < 40% significantly associated with higher 5-year MACE rate
Duration of exposure to AIT
- Median duration of exposure to AIT (Q1; Q3 1.3; 4.7)
- 2.7 months
Perioperative mortality
- Overall perioperative mortality
- 2.0%
Original publication
Major adverse cardiac events in patients with amiodarone-induced thyrotoxicosis undergoing thyroidectomy: a multicenter study. Eur Thyroid J. Published 27 March 2026. doi:10.
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